NUTRACEUTICAL & FOOD
When delivering an active principle through oral route, limited bioavailability is achieved, due to incomplete or erroneous absorption through the gastrointestinal tract, degradation by pH and enzymatic activity. Therefore, a dosage form must be formulated taking into account these various obstacles introduced by the gastrointestinal tract in order to reach the colon and release the drug.
The encapsulation process and the use of specific polymers permits molecules stability to ensure their absorption.
Different strategies and biomaterials have been investigated for oral delivery system, especially biodegradable biomaterials, which are safe, non toxic, not expensive and compatible with excipients in the formulation. Therefore, they belong to the category “generally regarded as safe” (GRAS).
Furthermore, since muco-adhesion can prolong the residence time at the absorption sites, Nanomnia uses polymers that allow bio-adhesion to mucous membranes in the gastrointestinal tract.